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Objective herpesviruses are widely distributed in the lower respiratory tract, yet no study has comprehensively characterized their clinical features and prognostic impact in severe pneumonia In intensive care unit (icu) patients in whom bronchoalveolar lavage fluid (balf) was analyzed for suspected infectious pulmonary disease, we investigated the association of herpes simplex virus (hsv) in the balf with lung injury and patient outcome. Method in this multicenter, retrospective study, we included severe pneumonia patients who underwent bronchoalveolar lavage fluid (balf) metagenomic testing in intensive.
Debate continues as to whether the detection of herpes simplex virus (hsv) in lower respiratory tract specimens, especially from immunosuppressed, critically ill patients, and organ transplant recipients, represents a true clinical infection requiring therapy or innocuous viral shedding secondary to severe underlying illness Similarly, herpes simplex virus (hsv), varicella zoster virus and human herpesviruses 6 and 7 can also be responsible for acute manifestations in lung transplant patients. To identify the impact of virus detection in bronchoalveolar lavage (bal) fluid, we analyzed bal samples from 87 consecutive lung transplant recipients for human herpesvirus (hhv)‐6, epstein‐barr virus, herpes simplex virus 1/2, cytomegalovirus, respiratory syncytical virus and adenovirus by pcr.
However, all studies had a high risk of bias and overall evidence is low
Surveillance bronchoscopies with bronchoalveolar lavage (bal) and transbronchial biopsies (tbb) are primarily used to detect acute cellular rejection (acr) or infection in lung transplant (ltx) recipients We previously identified a bal protein signature associated with chronic lung allograft dysfunction (clad) or death/retransplant in patients with. Prevalence of community respiratory viruses in lung transplant recipients in studies that used molecular methodsstudies on bronchoalveolar lavage fluid for the assessment of pneumonia in immunocompromised hosts*antiviral regimens for treatment and/or prophylaxis of seasonal influenza in adultsantimicrobial prophylaxis after lung. Bronchoalveolar lavage (bal) samples obtained from patients with signs of lower respiratory tract infection were tested and analysed for viral agents
Forty seven bal samples were obtained from 32 recipients (20 males and 12 females) of allogeneic haematological stem cell transplantation. Adult, mechanically ventilated patients with pneumonia and hsv type 1 detected in bronchoalveolar lavage (≥105 copies/ml) are eligible for participation and will be randomly allocated (1:1) to receive acyclovir (10 mg/kg body weight every 8 hours) for 10 days (or until.
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