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This study investigates the uptake and retention of stable fluorescent organosilica nanoparticles by macrophages, which play a vital role in scavenging environmental. To optimize the uptake of plga nps in macrophages we first undertook studies examining the uptake of three different sized rhodamine b labelled plga np populations. Hepatic nanoparticle uptake and distribution was initially studied as a drawback to be avoided because it entails a lack of specific selective distribution to other desired targets as.

We hypothesized that this system would enable us to parse out the roles of surface charge from size on nanoparticle internalization, leading us to identify the sensitivity of size and charge on. This review article explores the advantages liver macrophages have in nanoparticle uptake in comparison to other cells and tissues

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