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Although structurally not related to menthol, it produces an extreme sensation of cold,. Icilin inhibits transient receptor potential cation channel subfamily m. Here, we show that, to achieve full efficacy, icilin requires simultaneous elevation of cytosolic ca2+, either via permeation through trpm8 channels or by release from.

Icilin is a synthetic chemical compound recognized for its notable ability to induce an intense sensation of cold Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (trpa1) Icilin is a synthetic supercooling compound that elicits strong trpm8 activation (39)

The primary functional determinants of icilin sensitivity in htrpm8 include n799, d802,.

Icilin is a cooling agent that activates the novel cold receptors trpm8 (cmr1) and trpa1 (anktm1/trpn1), members of the trp ion channel family

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