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The pituitary stimulates another endocrine gland to secrete its hormone When either of these factors drops, the kidneys secrete an enzyme called renin. Then, this second hormone signals the pituitary to inhibit further secretion of the initial pituitary hormone.
In the blood, renin acts on a protein known as angiotensinogen, resulting in the release of angiotensin i This system is initiated by the kidneys, which respond to changes in blood flow or sodium concentration Renin converts angiotensinogen (a precursor of angiotensin that’s produced by your liver) to angiotensin i
(angiotensin is a hormone that narrows your blood vessels.)
Following its release into the bloodstream, renin acts on angiotensinogen, a glycopeptide continuously produced by the liver, forming angiotensin i. The renin enzyme circulates in the bloodstream and hydrolyzes (breaks down) angiotensinogen secreted from the liver into the peptide angiotensin i Angiotensin i is further cleaved in the lungs. Renin is an enzyme produced by the juxtaglomerular cells of the kidneys
Its primary function is to cleave angiotensinogen, converting it into angiotensin i Renin acts on angiotensinogen to produce angiotensin i Angiotensin i can be reacted with ace, chymase, ap/ace or ace2/ace to form angiotensin ii which acts on the at1 receptor.
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