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Conclusions reached in our initial report have been supported by a far greater experience Folic acid antagonists were introduced for the treatment of acute leukemia in 1948 by farber and his associates.1 early experience with parenteral administration of folic acid analogues was. Temporary remissions in acute leukemia as marked as those caused by aminopterin have been.
A general discussion is presented of the present status of folic acid antagonist therapy in acute leukemia in children and in other forms of incurable cancer For original use of aminopterin and methotrexate in the control of acute childhood leukemia, and for his constant leadership in the search for chemical agents against cancer Conclusions reached in our initial.
Interestingly, controlled calorie restriction has recently been shown to further improve the rate of molecular remission of children with acute lymphoblastic leukemia and is now being tested in a.
The difficulty in managing acute leukemia in children is enhanced by the occurrence of neurological manifestations It is especially true when this component of the disease occurs,. The latter were believed to have experienced temporary remissions In addition to aminopterin, the latter trials used another folate antagonist, amethopterin, which came to be called methotrexate and was to become a mainstay of cancer therapy
Methotrexate (mtx), a folic acid analog known initially as amethopterin, was discovered as an effective treatment for acute leukemia in 1950,1 and for other solid tumors during the 1950s. Farber and his colleagues (1) used the first effective antileukemic agent, aminopterin, to treat children with acute lymphatic leukemia In many of the subsequent studies over the.
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